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The objective of a knowledge management system (KMS) in the field of Nuclear Safety Assessment is to keep competences in expertise and research at the best level. This contribution proposes a diagram of KM organization associated with the Eurosafe Safety Assessment Guide project proposal. The aim of the KM action is to test and bring forward a generic and perennial method of knowledge management adapted to the safety culture. It will be interested to support the access to information useful for the practices of expertise by organizing a knowledge mapping, supporting the exchanges of know-how by the consolidation of a competence network and the externalisation of expert knowledge. This article presents the actions in progress at AVN, GRS and IRSN, and suggests some principles based on experience feedbacks drawn from the literature. It is not supposed to be exhaustive but rather to encourage other Technical Support Organizations to take part in this KM action associated with the technical project. We suggest to organize the KM action in three phases (1) definition of a KM Strategy adapted to the technical project (2) implementation of KM selected actions (actors sensitization, tests of KM methods…) (3) choice and fulfilment of effective and perennial KM solutions