Persistent Hypercalcemia After Parathyroidectomy in an Adolescent and Effect of Treatment With

olescence and is more likely to persist after parathyroid-ectomy than in adults. Cinacalcet HCl is a new calcimi-metic that has been used successfully for the treatment of primary and secondary hyperparathyroidism in adults, but its use in adolescents has not been reported. Case: A 16 year-old male presented with hypercalcemia that had persisted for 1.5 years after parathyroidectomy for primary hyperparathyroidism. Parathyroid hormone (PTH) concentrations were nonsupressed despite a mean (SD) serum calcium concentration of 2.82 (0.06) mmol/L. Treatment with cinacalcet HCl was initiated and a pharmacodynamic profile was obtained for serum calcium, phosphorus, and PTH. Cinacalcet HCl normal-ized serum calcium. The changes in PTH were assay dependent