Some Aspects of Chronic Heart Failure Pathogenesis

The given review deals with the role of left ventricular diastolic dysfunction in chronic heart failure (CHF) pathogenesis. Left ventricular dysfunction, caused by disturbances in active relaxation of myocardium and ventricular blood filling, is indicated in 15-30 % of patients with clinical manifestations of CHF and more than half of those aged above 75 years. The similarity of symptoms of left ventricular diastolic dysfunction and CHF caused by systolic dysfunction complicates diagnostics of the pathology. Due to this the timely diagnostics of patients with left ventricular diastolic dysfunction and seek for new approaches of treatment seems to be an urgent problem of modern clinical cardiology. The main method for studying diastolic dysfunction is Doppler echocardiography. Transmitral diastolic flow indicates diastolic function. Three types of diastolic dysfunction: hypertrophic, pseudonormal and restrictive are known nowadays. The restrictive type of left ventricular diastolic dysfunction causes the most severe course of heart failure. It is shown the necessity of elaboration of new methods of diagnostics and rational pharmacological correction of diastolic dysfunction at CHF, taking into consideration the severity of the disease