ORIGINAL ARTICLE Glucose Metabolism in Patients With Schizophrenia Treated With Atypical Antipsychotic Agents A Frequently Sampled Intravenous Glucose Tolerance Test and Minimal Model Analysis

Background: While the incidence of new-onset diabe-tes mellitus may be increasing in patients with schizo-phrenia treated with certain atypical antipsychotic agents, it remains unclear whether atypical agents are directly affecting glucose metabolism or simply increasing known risk factors for diabetes. Objective: To study the 2 drugs most clearly impli-cated (clozapine and olanzapine) and risperidone using a frequently sampled intravenous glucose tolerance test. Design: A cross-sectional design in stable, treated pa-tients with schizophrenia evaluated using a frequently sampled intravenous glucose tolerance test and the Berg-man minimal model analysis. Setting: Subjects were recruited from an urban com-munity mental health clinic and were studied at a gen