COUPLING WITH HMC COMPLEX AUTOMATA FRAMEWORK

The process can be categorized in various stages:- initial injury;- an inflammatory stage;- granulation,- extracellular matrix deposition- finally blood vessel remodelling. It is a multi-scale multi-science system, covering a range of phenomena from biology (cell signaling and cycles), physics (haemodynamics, convection-diffusion, transport), chemistry (drug uptake, reaction models) and medicine, and crossing many orders of magnitude in temporal and spatial scales (figure 1). COAST is structured along 3 main lines: ● Mathematical formulation of a Complex Automaton, based on a Scale Separation Map and information exchange between different processes. ● Development of a COAST simulation environment. ● Validation using a challenging biomedical application related to coronary artery disease (in-stent restenosis). A stenosis is an abnormal narrowing in a blood vessel. A possible treatment consists of deploying a metal mesh (stent) against the wall of the artery. An inflammatory response can lead to a restenosis (figure 2). It occurs in approximately 5-10 % of patients following procedures involving stent deployment. Modeling of blood flow needs a detailed description of Blood Cells near the vessel wall but only a simplified bulk flow description inside the vessels, plus a proper coupling of these two different scales. Where those domains overlap we can think of