Molecular analysis of uniparental disomy in a Thai patient with

Prader-Willi syndrome (PWS) is a congenital developmental disorder of childhood, characterized by mental retardation, neonatal hypotonia and feeding difficulty followed by excessive eating in childhood which leads to obesity. It is caused by an absence of 15q11-13 region on a paternally derived chromosome 15. This is an imprinted region which contains several imprinted genes. The majority of PWS cases are caused by an interstitial deletion of the PWS critical region. Some are cause