Androgens have been proposed to be actively produced in situ in human prostate cancer. These locally produced androgens have also been considered to play important roles in the pathogenesis and development of prostate cancer. Therefore, it is important to examine the status of this in situ androgen metabolism and/or synthesis in detail in order to improve the clinical response to hormonal therapy in patients diagnosed with prostate cancer. Several studies have previously demonstrated the expression of androgen-producing enzymes such as 5a-reductase types 1 and 2, and 17b-hydroxysteroid dehydrogenase type 5 (17b-HSD5), in human prostate carcinoma cells. However, their biological significance has remained largely unknown. In this study, we ev...
In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in pro...
Contains fulltext : 96367.pdf (publisher's version ) (Open Access)Considerable lev...
In the fight against androgen-sensitive prostate cancer, the enzyme 17β-hydroxysteroid dehydrogenase...
Genes that are responsible for variations in drug and hormonal responses are sometimes also associat...
Malignant prostate cancer (PCa) is usually treated with androgen deprivation therapies (ADTs). Recur...
Androgen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (C...
Androgen metabolism was investigated in the human prostate cancer cell lines (HPC-36M, DU145, PC-3/M...
Androgens play an important role in prostate cancer (PCa) development and progression. Although andr...
The presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate car...
The enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT), performs key func...
The metabolism of androgens in prostatic carcinoma has not been sufficiently studied so far, mainly ...
BACKGROUND: Prostate trophism depends on DHT formed from T by the enzyme 5\u3b1-R. Two 5\u3b1-R isof...
The development of human benign or malignant prostatic diseases is closely associated with androgens...
International audienceWe studied the expression level and cell-specific expression patterns of 5alph...
In normal prostatic epithelial cells, androgen receptor (AR) expression and activity are regulated b...
In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in pro...
Contains fulltext : 96367.pdf (publisher's version ) (Open Access)Considerable lev...
In the fight against androgen-sensitive prostate cancer, the enzyme 17β-hydroxysteroid dehydrogenase...
Genes that are responsible for variations in drug and hormonal responses are sometimes also associat...
Malignant prostate cancer (PCa) is usually treated with androgen deprivation therapies (ADTs). Recur...
Androgen-deprivation therapy for prostate cancer (PC) eventually leads to castration-resistant PC (C...
Androgen metabolism was investigated in the human prostate cancer cell lines (HPC-36M, DU145, PC-3/M...
Androgens play an important role in prostate cancer (PCa) development and progression. Although andr...
The presence and possible role of androgen-metabolizing enzymes in androgen-independent prostate car...
The enzyme 5α-reductase, which converts testosterone to dihydrotestosterone (DHT), performs key func...
The metabolism of androgens in prostatic carcinoma has not been sufficiently studied so far, mainly ...
BACKGROUND: Prostate trophism depends on DHT formed from T by the enzyme 5\u3b1-R. Two 5\u3b1-R isof...
The development of human benign or malignant prostatic diseases is closely associated with androgens...
International audienceWe studied the expression level and cell-specific expression patterns of 5alph...
In normal prostatic epithelial cells, androgen receptor (AR) expression and activity are regulated b...
In vitro studies reveal that androgens, oestrogens, and their metabolites play a crucial role in pro...
Contains fulltext : 96367.pdf (publisher's version ) (Open Access)Considerable lev...
In the fight against androgen-sensitive prostate cancer, the enzyme 17β-hydroxysteroid dehydrogenase...