PETmolecular imaging of 15O-labeled water is the gold standard for measuring blood flow in humans. However, this requires an on-site cyclotron to produce the short-lived 15O tracer, which is cost-prohibitive for most clinical PET centers. The purpose of this study was to determine if the early uptake of 18F-FDG could be used to measure regional blood flow in tumors in the absence of 15O-water.Methods: PET scanswere obtained in patients be-ing evaluated for tumor perfusion and glucose metabolism in a phase I dose-escalating protocol for endostatin, a novel antian-giogenic agent. A 2-min perfusion scanwas performedwith a bo-lus injection of 2,220 MBq (60 mCi) of 15O-water, which was followed by a 370-MBq (10 mCi) dose of 18F-FDG. Four sequen-...
Purpose: As the interest in antiangiogenesis therapy in oncology is rising, the need for in vivo tec...
Accurate and early evaluation of tumor response to chemotherapy is a growing clinical need for optim...
Purpose: To investigate the kinetics of 18F-fluorodeoxyglucose (18F-FDG) by positron emission tomogr...
Noninvasive methods for quantifying tumor blood flow (TBF) have a potentially important role in the ...
Hypoxia is a characteristic feature of malignant tumors that should be evaluated before the start of...
International audienceThe evaluation of drug pharmacodynamics and early tumour response are integral...
Tumor delineation using noninvasive medical imaging modalities is important to determine the target ...
The purpose of this study was to prospectively evaluate the relationship between tumor blood flow an...
Quantification of tumor perfusion using radioactive water (H215O) and PET is a promising method for ...
PET and 15O-labeled water (H215O) can be used to noninvasively monitor tumor perfusion. This allows ...
The use of dynamic 18F-FDG PET to determine changes in tumor metabolism requires tumor and plasma ti...
Contains fulltext : 71217.pdf (publisher's version ) (Closed access)Tumor delineat...
UNLABELLED: The use of dynamic (18)F-FDG PET to determine changes in tumor metabolism requires tumor...
As a widely used diagnostic tool, 18F-FDG PET/CT combines anatomic imaging with functional imaging a...
The use of dynamic (18)F-FDG PET to determine changes in tumor metabolism requires tumor and plasma ...
Purpose: As the interest in antiangiogenesis therapy in oncology is rising, the need for in vivo tec...
Accurate and early evaluation of tumor response to chemotherapy is a growing clinical need for optim...
Purpose: To investigate the kinetics of 18F-fluorodeoxyglucose (18F-FDG) by positron emission tomogr...
Noninvasive methods for quantifying tumor blood flow (TBF) have a potentially important role in the ...
Hypoxia is a characteristic feature of malignant tumors that should be evaluated before the start of...
International audienceThe evaluation of drug pharmacodynamics and early tumour response are integral...
Tumor delineation using noninvasive medical imaging modalities is important to determine the target ...
The purpose of this study was to prospectively evaluate the relationship between tumor blood flow an...
Quantification of tumor perfusion using radioactive water (H215O) and PET is a promising method for ...
PET and 15O-labeled water (H215O) can be used to noninvasively monitor tumor perfusion. This allows ...
The use of dynamic 18F-FDG PET to determine changes in tumor metabolism requires tumor and plasma ti...
Contains fulltext : 71217.pdf (publisher's version ) (Closed access)Tumor delineat...
UNLABELLED: The use of dynamic (18)F-FDG PET to determine changes in tumor metabolism requires tumor...
As a widely used diagnostic tool, 18F-FDG PET/CT combines anatomic imaging with functional imaging a...
The use of dynamic (18)F-FDG PET to determine changes in tumor metabolism requires tumor and plasma ...
Purpose: As the interest in antiangiogenesis therapy in oncology is rising, the need for in vivo tec...
Accurate and early evaluation of tumor response to chemotherapy is a growing clinical need for optim...
Purpose: To investigate the kinetics of 18F-fluorodeoxyglucose (18F-FDG) by positron emission tomogr...