The highly protective effect of newborn circumcision against invasive penile cancer. Pediatrics 2000;105:E36

ABSTRACT. Objective. We determined the relation be-tween newborn circumcision and both invasive penile can-cer (IPC) and carcinoma in situ (CIS) among adult male members of a large health maintenance organization. Subjects and Methods. Circumcision status was ascer-tained by a combination of pathology reports, medical record review, and questionnaires for 213 adult male members of a large prepaid health plan who were diag-nosed with IPC or CIS. Results. Of 89 men with IPC whose circumcision sta-tus was known, 2 (2.3%) had been circumcised as new-borns, and 87 were not circumcised. Of 118 men with CIS whose circumcision status was known, 16 (15.7%) had been circumcised as newborns. Conclusions. Our results confirm the highly protec-tive effect of newborn circumcision against IPC and the less protective effect against CIS. Pediatrics 2000;105(3)