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network growth. We validate our simulation results against HUVEC cultures using time-resolved image analysis and find that our simulations vascular plexus, expands through angiogenic sprouting. Later, association of the primary vascular plexus with additional cell aspects require additional cell types and guidance cues. Thus, experimentally, we must distinguish the endothelial cells’ intrinsic ability to form vascular-like patterns from those lation by external l, human umbilical Developmental Biology 289types, including pericytes and smooth muscle cells, andquantitatively reproduce in vitro vasculogenesis and subsequent in vitro remodeling