Add to ORKGAIM: To establish and validate the mutation testing for identification and characterization of hereditary non-polyposis colorectal cancer (HNPCC) in suspected Chinese patients. METHODS: Five independent Chinese kindreds with HNPCC fulfilling the classical Amsterdam criteria were collected. Genomic DNA was extracted after informed consent was obtained. The coding region of hMSH2 and hMLH1 genes was detected by polymerase chain reaction (PCR) and denaturing high-performance liquid chromatography (DHPLC). Mutations identified in the proband by DHPLC were directly sequenced using a 377 DNA sequencer, analyzed with a basic local alignment tool (BLAST), and tested in the corresponding famil
BACKGROUND: Clinical screening is still the first-line approach to identification of families with h...
BACKGROUND: Clinical screening is still the first-line approach to identification of families with h...
Hereditary non-polyposis colorectal cancer (HNPCC) is a clinical syndrome characterised by an inheri...
AIM: To establish and validate the mutation testing for identification and characterization of hered...
Background:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease due t...
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly-inherited cancer-suscep...
AIM: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly-inherited cancer-s...
AIM: To explore the clinicopathological and molecular genetic features of hereditary nonpolyposis co...
Abstract The aim of this study was to investigate the clinical value of different criteria and to un...
Hereditary non-polyposis colorectal cancer (HNPCC), the most common type of hereditary colorectal ca...
OBJECTIVES To analyse the diagnosis and treatment of 24 hereditary nonpolyposis colorectal cancer (H...
To analyze the diagnosis and treatment of 16 hereditary nonpolyposis colorectal cancer (HNPCC) kindr...
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal syndrome largely caused by germlin...
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal syndrome largely caused by germlin...
AIM: To analyze the diagnosis and treatment of 16 hereditary nonpolyposis colorectal cancer (HNPCC) ...
BACKGROUND: Clinical screening is still the first-line approach to identification of families with h...
BACKGROUND: Clinical screening is still the first-line approach to identification of families with h...
Hereditary non-polyposis colorectal cancer (HNPCC) is a clinical syndrome characterised by an inheri...
AIM: To establish and validate the mutation testing for identification and characterization of hered...
Background:Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant disease due t...
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly-inherited cancer-suscep...
AIM: Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominantly-inherited cancer-s...
AIM: To explore the clinicopathological and molecular genetic features of hereditary nonpolyposis co...
Abstract The aim of this study was to investigate the clinical value of different criteria and to un...
Hereditary non-polyposis colorectal cancer (HNPCC), the most common type of hereditary colorectal ca...
OBJECTIVES To analyse the diagnosis and treatment of 24 hereditary nonpolyposis colorectal cancer (H...
To analyze the diagnosis and treatment of 16 hereditary nonpolyposis colorectal cancer (HNPCC) kindr...
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal syndrome largely caused by germlin...
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal syndrome largely caused by germlin...
AIM: To analyze the diagnosis and treatment of 16 hereditary nonpolyposis colorectal cancer (HNPCC) ...
BACKGROUND: Clinical screening is still the first-line approach to identification of families with h...
BACKGROUND: Clinical screening is still the first-line approach to identification of families with h...
Hereditary non-polyposis colorectal cancer (HNPCC) is a clinical syndrome characterised by an inheri...