Association of Total Insulin-Like Growth Factor-I, Insulin-Like Growth Factor Binding Protein-1 (IGFBP-1), and IGFBP-3 Levels with Incident Coronary Events and Ischemic Stroke

Context: Prior observational studies have demonstrated that the GH/IGF axis is associated with cardiovascular disease. However, this association has not been extensively studied among older adults. Objective: The objective of this study was to assess the association between levels of total IGF-I and IGF binding proteins (IGFBP-1, IGFBP-3) and risk of incident coronary events and ischemic stroke. Design and Participants: A case-cohort analysis was con-ducted among adults 65 yr and older in the Cardiovascular Health Study. Main Outcome Measures: A total of 534 coronary events [316 non-fatal myocardial infarctions (MIs), 48 fatal MIs, and 170 fatal coro-nary heart disease events] and 370 ischemic strokes were identified on follow-up. Comparison subjects were 1122 randomly selected par-ticipants from the Cardiovascular Health Study. Results: Mean follow-up time was 6.7 yr for coronary events, 5.6 y