Formulation processes:

Different SCF processes [1-3] are being developed to design composite particles with several purposes among which bio-availability enhancement of poorly-soluble compounds can be obtained by incorporating the active in a fast-dissolving hydrophilic excipient [4-9]. For example, on figure 1, is presented a picture of micro-spheres of a drug co-precipitated with PEG from a CO2-saturated suspension according to the Fluid-Assisted Micro-Encapsulation process derived from the PGSS concept