CASE REPORT Copper Deficiency Myeloneuropathy Resembling B12 Deficiency: Partial Resolution of MR Imaging Findings with

SUMMARY: Copper deficiency has been associated with a clinical syndrome, myeloneuropathy. Ra-diographic changes resembling B12 deficiency in the cervical spinal cord have been described. We present a case of copper deficiency myeloneuropathy, with cervical MR imaging findings resembling B12 deficiency, which partially reversed following copper supplementation. This is, to our knowledge, the first described case of radiographic improvement with copper supplementation. Copper deficiency is an increasingly reported but under-recognized cause of neurologic dysfunction. This poten-tially treatable disorder manifests clinically as a profound sen-sory ataxia and can be associated with signal-intensity change in the dorsal columns of the spinal cord, resembling B12 defi-ciency. We present a patient with copper deficiency myelo-neuropathywhohadpartial reversal of theMR imaging signal-intensity changes in the dorsal columns after copper replacement therapy. Case Report A 53-year-old woman was referred for neurologic evaluation of pe