Increased Plasma Concentrations of Cytoskeletal and Ca2-Binding Proteins and Their Peptides in Psoriasis Patients

pathogenesis are not fully understood and might be elucidated by identifying novel disease-related molec-ular markers, including autoantigens. METHODS: We used 2 proteomic methods to analyze plasma samples from 20 psoriasis patients and 20 matched healthy donors. The first method focused on evaluating changes in glycoprotein concentrations and the plasma proteome, and the second method assessed endogenous proteolytic activity by analyzing the low molecular weight component of plasma. RESULTS: The integrated proteomic and peptidomic analysis identified a number of proteins and their frag-ments present at different concentrations in the plasma of psoriasis patients and healthy donors. We used ELISA to independently verify the changes in the con