Common Carp Pituitary in Field Efficacy Trials Prepared by:

Spawning aids such as common carp pituitary (CCP), luteinizing hormone-releasing hormone analogue, and human chorionic gonadotropin are routinely used in fisheries programs to induce gamete maturation in fish to enhance fish propagation programs. The U.S. Food and Drug Administration has authorized the use of CCP under the Compassionate Investigational New Animal Drug (INAD) Exemption #8391 for the purpose of gathering efficacy data to support a new animal drug approval for CCP. During calendar year 2007 (CY07), 14 INAD trials were conducted to evaluate the efficacy of CCP to induce gamete maturation in a variety of fish species. Trials involved 6,167 treated fish and were conducted at seven different fish hatcheries, including one United States Department of Agriculture- Agriculure Research Station, four state hatcheries and two private hatcheries. Efficacy was determined by whether or not treated fish (1) produced or yielded eggs or milt, or (2) produced or yielded more eggs or milt than untreated fish. Overall results of trials conducted during this period 2indicated that approximately 93 % of the trials appeared efficacious, while 7 % of the trials were characterized as inconclusive