A Patient with a Leg Rash, Pedal Edema, Renal Failure, and

A 57-year-old man was referred for assessment and management of malaise and leg edema, which had in-creased 2 weeks after the onset of a productive cough, for which clarithromycin had been prescribed. His course was complicated by the development of a pru-ritic skin eruption. The patient’s medical history in-cluded type II diabetesmellitus of 5 years ’ duration and stage III chronic kidney disease. He also had a chronic infection with hepatitis C virus (HCV)6 (genotype 1A) and had been lost to follow-up for the previous 19 years. Medications included antihypertensive drugs (calcium channel blocker, -blocker, angiotensin-converting enzyme inhibitor, and furosemide), a lipid-lowering drug (ezetimibe), analgesics (hydromor-phone HCl and acetaminophen), and ipratropiu