Add to ORKGCeramide, a product of sphingomyelin hydrolysis, is now recognized as an intracellular lipid messenger, which mediates the effects of extracellular agents on cellular growth, differentiation and apoptosis. Recently, ceramide has been implicated in the regulation of phospholipase D (PLD). In this study, we examined the effects of ceramide on the activity and mRNA level of PLD during apoptotic process in FRTL-5 thyroid cells. C2-ceramide (N-acetyl sphingosine) induced apoptosis in FRTL-5 thyroid cells. Fluorescent staining showed that ceramide induced the typical features of apoptosis including condensed or fragmented nuclei. DNA fragmentation was also observed by agarose gel electrophoresis. Flow cytometric cell cycle analysis showed more cl...
International audienceIt is well known that tumor formation arises from the imbalance between cell d...
AbstractSphingolipids such as ceramide and sphingosine are putative intracellular signal mediators i...
Ceramide has been reported to induce typical apoptotic changes in nuclei incubated in a cell-free sy...
AbstractThe novel lipid second messenger, ceramide, induced apoptosis in PC12 cells as determined mo...
Apoptosis, also called programmed cell death, is physiologically and pathologically involved in cell...
AbstractProgrammed cell death is an important physiological response to many forms of cellular stres...
Sodium nitroprusside (SNP), a nitric oxide (NO) donor has been recognized as an inducer of apoptosis...
C2-ceramide, a cell-permeable analogue of ceramide, induced significant, dose- and time-dependent de...
AbstractThe generation of ceramides by the action of acidic and/or neutral sphingomyelinases has bee...
The activation of sphingomyelinases leading to the generation of ceramide has been implicated in var...
The genus Sphingobacterium, whose members are Gram-negative non-fermentative rods, possesses ceramid...
In the skin, the generation of intracellular ceramide may provide a link between an extracellular si...
Ceramide (Cer) has been implicated in the regulation of apoptosis. In this study, we elevated cellul...
Ceramide has been reported to induce typical apoptotic changes in nuclei incubated in a cell-free sy...
Ceramide is synthesized upon stimuli, and induces apoptosis in renal tubular cells (RTCs). Sphingos...
International audienceIt is well known that tumor formation arises from the imbalance between cell d...
AbstractSphingolipids such as ceramide and sphingosine are putative intracellular signal mediators i...
Ceramide has been reported to induce typical apoptotic changes in nuclei incubated in a cell-free sy...
AbstractThe novel lipid second messenger, ceramide, induced apoptosis in PC12 cells as determined mo...
Apoptosis, also called programmed cell death, is physiologically and pathologically involved in cell...
AbstractProgrammed cell death is an important physiological response to many forms of cellular stres...
Sodium nitroprusside (SNP), a nitric oxide (NO) donor has been recognized as an inducer of apoptosis...
C2-ceramide, a cell-permeable analogue of ceramide, induced significant, dose- and time-dependent de...
AbstractThe generation of ceramides by the action of acidic and/or neutral sphingomyelinases has bee...
The activation of sphingomyelinases leading to the generation of ceramide has been implicated in var...
The genus Sphingobacterium, whose members are Gram-negative non-fermentative rods, possesses ceramid...
In the skin, the generation of intracellular ceramide may provide a link between an extracellular si...
Ceramide (Cer) has been implicated in the regulation of apoptosis. In this study, we elevated cellul...
Ceramide has been reported to induce typical apoptotic changes in nuclei incubated in a cell-free sy...
Ceramide is synthesized upon stimuli, and induces apoptosis in renal tubular cells (RTCs). Sphingos...
International audienceIt is well known that tumor formation arises from the imbalance between cell d...
AbstractSphingolipids such as ceramide and sphingosine are putative intracellular signal mediators i...
Ceramide has been reported to induce typical apoptotic changes in nuclei incubated in a cell-free sy...