Journal of Leukocyte Biology 36:341-355 (1984) REVIEW The Numerous Postulated Biological Manifestations of lnterleukin-1

Over the past 25 years there has been an ever-expanding interest in the mediators that control the immune response [98,133]. One of these is produced by macrophages and was first called “lymphocyte activating factor ” [49-51] but is now designated “interleukin-l ” (IL-i) [118]