nutrition, Pharmacology and Toxicology Enzyme Activities Associated with Carcinogen Metabolism in Liver and Nonhepatic Tissues of Rats Maintained on High Fat and

ABSTRACT The influence of high fat or food-restricted diets on key enzymes associated with polycyclic aro matic hydrocarbon metabolism was assessed in liver, lung, kidney and stomach of rats. Animals had access ad libitum to the AIN-76A purified diet (control) or were given 65 % of the intake of controls for 3 wk. The high fat diet was isoenergetic to the control diet by substi tuting com oil for equal energy from carbohydrate and addition of cellulose to obtain equal energy density. Ac tivities of arylhydrocarbon hydroxylase and 7-ethoxycou-marin O-deethylase were significantly increased in lungs of food-restricted rats and decreased by the high fat diet but were not altered in liver. Both diets increased aryl hydrocarbon hydroxylase approximately twofold in kidney. Glucose 6-phosphate and 6-phosphogluconat