EFFECT OF SULPIRIDE ON BODY WEIGHT AFTER CHRONIC ADMINISTRATION IN MALE MICE

The influence of dopamine on feeding behaviour is a well-documented fact. Ho-wever, while it seems evident that stimu-lation of D1 receptors produces a decrea-sed body weight in rodents, the role of D2 receptors remains less clear (Ferrari, Pe-lloni and Giuliani, 1992). Sulpiride is a substituted benzamide which selectively blocks dopamine D2 re-ceptors (Jenner and Marsden, 1979), also exhibiting a high affinity for D3 receptors (Giros, 1991). Traditionally, it is conside-red as an atypical neuroleptic drug due to the low frequency of its extrapyramidal si-de effects and its antidepressant actio