BRIEF COMMUNICATION Hereditary Retinoblastoma, Lipoma, and Second Primary Cancers

Malignant connective tissue tumors, particularly soft-tissue sarcomas and os-teosarcomas, are recognized complica-tions of hereditary retinoblastoma (1,2). An apparent high frequency of lipomas, which are benign tumors of adipose tis-sue, among survivors of retinoblastoma was noted by a patient with hereditary retinoblastoma attending a recent meet-ing of the New England Retinoblastoma Family Support Group. Because we knew of no published reports of an as-sociation between germline mutations in the retinoblastoma (RB1) gene and lipo-mas, we examined data from a cohort of 898 retinoblastoma survivors, diagnosed at several New York hospitals durin