Research summary

down of Eomes function results in an endoderm defi-ciency. We find that Eomes binds a site in the cas pro-moter that is essential for high-level cas expression. Finally, we show that Eomes physically interacts with both Bon and Gata5, suggesting that Eomes assembles a transcriptional complex on the cas promoter. Thus, in addition to its role in mesoderm formation and pat