Rate of Synthesis of lgG within the Blood-Brain Barrier and the lgG Index Compared in the Diagnosis of Multiple Sclerosis

Receiver-operating characteristic curves of the IgG synthesis rate and the lgG index show that the IgG index has better discriminating properties with respect to multiple sclerosis. This, added to the fact that the precision of determining the index is much higher than that of the synthesis rate, makes the IgG index the parameter of choice in the diagnosis of multiple sclerosis. AdditIonal Keyphrases: cerebrospinal fluid albumin re-ceiver-operating characteristic curves Synthesis of IgG on the nervous-system side of the blood-brain barrier (BBB) can be evidence of an immunopatho-genic basis for multiple sclerosis (MS). ’ However, controver-sy has arisen as to which calculation of the amount of IgO synthesized, the IgG synthesis rate (IgG Syn) or the so-called IgG index, is the more dependable expression of intra