alleles in chronic viral hepatitis B

AIM: To investigate the association between curative effects of interferon-a and partial human leucocyte antigen (HLA) II alleles in chronic viral hepatitis B. METHODS: Sixty patients with chronic viral hepatitis B in Shanghai were treated with a standard course of treatment with interferon-a for 6 mo. HLA-DRB1,-DQA1, and-DQB1 alleles were detected by polymerase chain reaction-sequence specific primer (PCR-SSP) method. RESULTS: Frequencies of HLA-DRB1*04 (P<0.025) and HLA-DQA1*0303 (P<0.01) in non-responders were significantly higher than those in partial and complete responders. Frequencies of HLA-DQA1*0505 (P<0.025) and HLA-DQB1*0301 (P<0.005) in partial and complete responders were significantly higher than those in non