Differential induction of peroxisomal b-oxidation enzymes by clofibric acid and aspirin in piglet tissues

Differential induction of peroxisomal b-oxidation enzymes by clofibric acid and aspirin in piglet tissues. Am J Physiol Regulatory Integrative Comp Physiol 281: R1553–R1561, 2001.—Peroxisomal b-oxidation (POX) of fatty acids is im-portant in lipid catabolism and thermogenesis. To investi-gate the effects of peroxisome proliferators on peroxisomal and mitochondrial b-oxidation in piglet tissues, newborn pigs (1–2 days old) were allowed ad libitum access to milk re-placer supplemented with 0.5 % clofibric acid (CA) or 1% aspirin for 14 days. CA increased ratios of liver weight to body weight (P, 0.07), kidney weight to body weight (P, 0.05), and heart weight to body weight (P, 0.001). Aspirin decreased daily food intake and final body weight but in-creased the ratio of heart weight to body weight (P, 0.01). In liver, activities of POX, fatty acyl-CoA oxidase (FAO), tota