Tangier disease is characterized by a deficiency of high-density lipoproteins and of their major protein constituent, apoiipoprotein (apo) A-i. We used high-resolution two-dimen-sional electrophoresis to examine the principal plasma apo-lipoproteins (A-I, A-Il, A-IV, E, C-Il, and C-Ill) of three persons with Tangier disease, one homozygous patient and his two heterozygous children, comparing the patterns with those for healthy subjects. Characteristic abnormalities were found in the distribution of the isoproteins of apo A-I, there being a normal concentration of pro apo A-I but dramatically de-creased concentrations of the other apo A-I isoproteins. We also found hitherto-undescribed polypeptide abnormalities in apo C-Ill: sialylated and n...
tein disorder is characterized by reduced plasma levels of high density lipoproteins (HDL) and eleva...
Mutations in ABCA1 have been shown to be the cause of Tangier disease (TD) and some forms of familia...
Mutations in ABCA1 have been shown to be the cause of Tangier disease (TD) and some forms of familia...
AbstractMajor disturbances of the lipoproteins in Tangier serum have been investigated using electro...
g/ml) were isolated from the plasma of normal indi-viduals (HDL) and seven homozygous patients with ...
Plasmas of patients with Tangier disease (TD) lack lipid-rich alpha-HDL which, in normal plasma, con...
A sensitive and rapid immunological detection method was used to screen for apolipoprotein A-IV vari...
Tangier disease (TD), caused by mutations in the gene encoding ATP-binding cassette 1 (ABCA1), is a ...
The technique of horizontal, thin layer isoelectric focusing was used to demonstrate the polymorphis...
Lipoprotein(a) consists of a low-density lipoprotein containing apolipoprotein (apo) B-100 and of th...
Abstract. We examined the ability of the plasma of a 52-yr-old male Tangier patient to effect the co...
Two groups of abnormal electrophoretic patterns of serum lipoproteins are reported here. One demonst...
AbstractTangier disease (TD) is an inherited disorder of lipid metabolism characterized by very low ...
A recently discovered familial lipoprotein disorder is characterized by reduced plasma levels of hig...
Elevated levels of low density lipoprotein (LDL) is a well known independent risk factor for atheros...
tein disorder is characterized by reduced plasma levels of high density lipoproteins (HDL) and eleva...
Mutations in ABCA1 have been shown to be the cause of Tangier disease (TD) and some forms of familia...
Mutations in ABCA1 have been shown to be the cause of Tangier disease (TD) and some forms of familia...
AbstractMajor disturbances of the lipoproteins in Tangier serum have been investigated using electro...
g/ml) were isolated from the plasma of normal indi-viduals (HDL) and seven homozygous patients with ...
Plasmas of patients with Tangier disease (TD) lack lipid-rich alpha-HDL which, in normal plasma, con...
A sensitive and rapid immunological detection method was used to screen for apolipoprotein A-IV vari...
Tangier disease (TD), caused by mutations in the gene encoding ATP-binding cassette 1 (ABCA1), is a ...
The technique of horizontal, thin layer isoelectric focusing was used to demonstrate the polymorphis...
Lipoprotein(a) consists of a low-density lipoprotein containing apolipoprotein (apo) B-100 and of th...
Abstract. We examined the ability of the plasma of a 52-yr-old male Tangier patient to effect the co...
Two groups of abnormal electrophoretic patterns of serum lipoproteins are reported here. One demonst...
AbstractTangier disease (TD) is an inherited disorder of lipid metabolism characterized by very low ...
A recently discovered familial lipoprotein disorder is characterized by reduced plasma levels of hig...
Elevated levels of low density lipoprotein (LDL) is a well known independent risk factor for atheros...
tein disorder is characterized by reduced plasma levels of high density lipoproteins (HDL) and eleva...
Mutations in ABCA1 have been shown to be the cause of Tangier disease (TD) and some forms of familia...
Mutations in ABCA1 have been shown to be the cause of Tangier disease (TD) and some forms of familia...