Santos RAS wrote the paper. Supported by Fundação de Amparo à Pesquisa do Estado

AIM: To measure circulating angiotensins at different stages of human cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes. METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplanta-tion, and healthy controls. Blood was collected to de-termine plasma renin activity (PRA), angiotensin (Ang) , Ang , and Ang-(1-7) levels using radioimmunoas-says. During liver transplantation, hemodynamic pa-rameters were determined and blood was simultane