Add to ORKGtion by forming a p53-Mdm2 complex on chromatin. Upon DNA damage-induced com-plex disruption, such latent p53 can be activat-ed, but in cells overexpressing Mdm2 because o
MDM2 is an important negative regulator of p53 tumor suppressor. In this study, we sought to investi...
Exposure of human pre-osteoclasts to the MDM2 antagonist Nutlin-3 activated the p53 pathway and sign...
Recent advances in the field of pharmacological activation of the p53 tumor suppressor are beginning...
p53 is a key component of the protein network that regulates cell cycle progression and prevents ca...
The MDM2-p53 pathway has a prominent oncogenic function in the pathogenesis of various cancers. Nutl...
Human hepatocellular carcinoma (HCC) is the fifth most common cancer and is associated with poor pro...
Wild-type p53 is commonly expressed in melanoma but does not appear to be effective in the induction...
The interaction of the tumorsupressor protein p53 with MDM2 is a potential target for small inhibito...
Six p53 wild-type cancer cell lines from infrequently p53-mutated entities (neuroblastoma, rhabdomyo...
Suppression of p53 activity is essential for proliferation and survival of tumor cells. A direct p53...
Suppression of p53 activity is essential for proliferation and survival of tumor cells. A direct p53...
The identification of the cellular targets of small molecules with anticancer activity is crucial to...
ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute lymphoblastic leukemia. It is res...
Wild-type p53 is a stress-responsive tumor suppressor and potent growth inhibitor. Genotoxic stresse...
With approximately 50% of tumours bearing mutations in the TP53 gene, the tumour suppressor p53 is o...
MDM2 is an important negative regulator of p53 tumor suppressor. In this study, we sought to investi...
Exposure of human pre-osteoclasts to the MDM2 antagonist Nutlin-3 activated the p53 pathway and sign...
Recent advances in the field of pharmacological activation of the p53 tumor suppressor are beginning...
p53 is a key component of the protein network that regulates cell cycle progression and prevents ca...
The MDM2-p53 pathway has a prominent oncogenic function in the pathogenesis of various cancers. Nutl...
Human hepatocellular carcinoma (HCC) is the fifth most common cancer and is associated with poor pro...
Wild-type p53 is commonly expressed in melanoma but does not appear to be effective in the induction...
The interaction of the tumorsupressor protein p53 with MDM2 is a potential target for small inhibito...
Six p53 wild-type cancer cell lines from infrequently p53-mutated entities (neuroblastoma, rhabdomyo...
Suppression of p53 activity is essential for proliferation and survival of tumor cells. A direct p53...
Suppression of p53 activity is essential for proliferation and survival of tumor cells. A direct p53...
The identification of the cellular targets of small molecules with anticancer activity is crucial to...
ETV6/RUNX1 (E/R) is the most common fusion gene in childhood acute lymphoblastic leukemia. It is res...
Wild-type p53 is a stress-responsive tumor suppressor and potent growth inhibitor. Genotoxic stresse...
With approximately 50% of tumours bearing mutations in the TP53 gene, the tumour suppressor p53 is o...
MDM2 is an important negative regulator of p53 tumor suppressor. In this study, we sought to investi...
Exposure of human pre-osteoclasts to the MDM2 antagonist Nutlin-3 activated the p53 pathway and sign...
Recent advances in the field of pharmacological activation of the p53 tumor suppressor are beginning...