Add to ORKGWhile cystic fibrosis transmembrane conductance regulator (CFTR) is well known to function as a Cl-channel, some mutations in the channel protein causing cystic fibrosis (CF) disrupt another vital physiological function, HCO3- transport. Pathological implications of derailed HCO3-transport are clearly demonstrated by the pancreatic destruction that accompany certain mutations in CF. Despite the crucial role of HCO3-in buffering pH, little is known about the relationship between cause of CF pathology and the molecular defects arising from specific mutations. Using electrophysiological techniques on basolaterally permeabilized preparations of microperfused native sweat ducts, we investigate
Objective: To compare differences in epithelial chloride conductance according to class of mutation ...
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein...
Cystic fibrosis (CF) is caused by mutations in autosomal recessive genes that code for proteins cyst...
Cystic fibrosis (CF) is a disease caused by mutations in the cystic fibrosis transmembrane conductan...
Aberrant HCO3- transport is a hallmark of cystic fibrosis (CF) and is associated with aberrant Cl--d...
AbstractThe specific effects of some mutations that cause cystic fibrosis suggest that reduced HCO3−...
Cystic fibrosis (CF) is caused by mutations in the gene encoding a cAMP-mediated chloride channel ca...
AbstractCystic fibrosis is a frequent autosomal recessive disorder that is caused by the malfunction...
Disruption of normal cystic fibrosis transmembrane conductance regulator-(CFTR)-mediated Cl- transpo...
Disruption of normal cystic fibrosis transmembrane conductance regulator- (CFTR)-mediated Cl(-) tran...
CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to cha...
Cystic fibrosis is an autosomal recessive disorder affecting the lungs, pancreas, intestines, sweat ...
Defects in processing and trafficking of cystic fibrosis transmembrane conductance regulator. Cystic...
The genetic disease, cystic fibrosis (CF), is caused by mutations in the cystic fibrosis transmembra...
Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease caused by mutations in the CF t...
Objective: To compare differences in epithelial chloride conductance according to class of mutation ...
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein...
Cystic fibrosis (CF) is caused by mutations in autosomal recessive genes that code for proteins cyst...
Cystic fibrosis (CF) is a disease caused by mutations in the cystic fibrosis transmembrane conductan...
Aberrant HCO3- transport is a hallmark of cystic fibrosis (CF) and is associated with aberrant Cl--d...
AbstractThe specific effects of some mutations that cause cystic fibrosis suggest that reduced HCO3−...
Cystic fibrosis (CF) is caused by mutations in the gene encoding a cAMP-mediated chloride channel ca...
AbstractCystic fibrosis is a frequent autosomal recessive disorder that is caused by the malfunction...
Disruption of normal cystic fibrosis transmembrane conductance regulator-(CFTR)-mediated Cl- transpo...
Disruption of normal cystic fibrosis transmembrane conductance regulator- (CFTR)-mediated Cl(-) tran...
CFTR is a dynamically regulated anion channel. Intracellular WNK1-SPAK activation causes CFTR to cha...
Cystic fibrosis is an autosomal recessive disorder affecting the lungs, pancreas, intestines, sweat ...
Defects in processing and trafficking of cystic fibrosis transmembrane conductance regulator. Cystic...
The genetic disease, cystic fibrosis (CF), is caused by mutations in the cystic fibrosis transmembra...
Cystic fibrosis (CF) is a lethal autosomal recessive genetic disease caused by mutations in the CF t...
Objective: To compare differences in epithelial chloride conductance according to class of mutation ...
Cystic fibrosis (CF) is a recessive genetic disease caused by mutations in a gene encoding a protein...
Cystic fibrosis (CF) is caused by mutations in autosomal recessive genes that code for proteins cyst...