Research Article Antimicrobial Activity of Flavonoids against Extended-Spectrum β-Lactamase (ESβL)-Producing

Purpose: In the present study, six flavonoids (5,7-dimethoxyflavanone-4’-O-β-D-glucopyranoside, 5,7-dimethoxyflavanone-4’-O-[2’’-O-(5’’’-O-trans-cinnamoyl)-β-D-apiofuranosyl]-β-D-glucopyranoside, naringenin-7-O-β-D-glucopyranoside, 5,7,3’-trihydroxy-flavanone-4’-O-β-D-glucopyranoside, rutin, and nicotiflorin) isolated from Galium fissurense, Viscum album ssp. album and Cirsium hypoleucum were screened against extended-spectrum β-lactamase producing multidrug-resistant (trimetoprime-sulphametoxazole, sulbactam-ampicillin, clavulonate-amoxicilin, ceftriaxon, cefepime, imipenem, ceftazidime, tobramicin, gentamicin, ofloxacin, ciprofloxacin) bacteria Klebsiella pneumoniae (ESβLs)