We report that a therapeutic dose of the antiresorptive bisphosphonate alendronate administered to skeletally mature rats for the duration of 16 weeks significantly blunted the anabolic response to a high dose SDZ PTS 893 in the tibia and femur but not in lumbar vertebra. Effects were seen at the level of bone mass (DEXA, pQCT) as well as in biomechanical tests. In one arm of this study, rats were switched to vehicle injections after 8 weeks on alendronate for another 8 weeks before being challenged with the anabolic stimulus (washout). This recovery period was insufficient for full recovery and the response to SDZ PTS 893 was still greatly reduced after this procedure. Serial pQCT-measurements suggest that part of the interaction happened ...
Purpose: This study was designed to investigate the effect of alendronate on the resorption of autog...
Summary Alendronate therapy has been associated with serious side effects. Altering the alendronate ...
There has been a conscious effort to address osteoporosis in the aging population. As bisphosphonate...
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, p...
Introduction:Parathyroid hormone increases bone strength primarily by stimulating bone formation, wh...
Summary: Administration of intermittent parathyroid hormone (PTH) promoted healing of tibial osseous...
Bisphosphonates and parathyroid hormone (PTH) represent the antiresorptive and anabolic classes of d...
Osteoporosis is one of the most prevalent bone diseases worldwide and is characterised by high level...
Intermittent administration of parathyroid hormone (PTH) leads to bone formation by increasing osteo...
International audiencePURPOSE: The purpose of this study was to determine whether bisphosphonate tre...
International audienceRecent studies demonstrate that bisphosphonates suppress bone resorption by le...
INTRODUCTION: The aim of this pilot study was to investigate the effect of long-term bisphosphonate...
PTH stimulates osteoblastic cells to form new bone and to produce osteoblast-osteoclast coupling fac...
UnlabelledAnti-resorptive and anabolic agents are often prescribed for the treatment of osteoporosis...
PURPOSE: The purpose of this study was to evaluate the effect of alendronates on bone remodeling aro...
Purpose: This study was designed to investigate the effect of alendronate on the resorption of autog...
Summary Alendronate therapy has been associated with serious side effects. Altering the alendronate ...
There has been a conscious effort to address osteoporosis in the aging population. As bisphosphonate...
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, p...
Introduction:Parathyroid hormone increases bone strength primarily by stimulating bone formation, wh...
Summary: Administration of intermittent parathyroid hormone (PTH) promoted healing of tibial osseous...
Bisphosphonates and parathyroid hormone (PTH) represent the antiresorptive and anabolic classes of d...
Osteoporosis is one of the most prevalent bone diseases worldwide and is characterised by high level...
Intermittent administration of parathyroid hormone (PTH) leads to bone formation by increasing osteo...
International audiencePURPOSE: The purpose of this study was to determine whether bisphosphonate tre...
International audienceRecent studies demonstrate that bisphosphonates suppress bone resorption by le...
INTRODUCTION: The aim of this pilot study was to investigate the effect of long-term bisphosphonate...
PTH stimulates osteoblastic cells to form new bone and to produce osteoblast-osteoclast coupling fac...
UnlabelledAnti-resorptive and anabolic agents are often prescribed for the treatment of osteoporosis...
PURPOSE: The purpose of this study was to evaluate the effect of alendronates on bone remodeling aro...
Purpose: This study was designed to investigate the effect of alendronate on the resorption of autog...
Summary Alendronate therapy has been associated with serious side effects. Altering the alendronate ...
There has been a conscious effort to address osteoporosis in the aging population. As bisphosphonate...