Seven new loci associated with age-related macular degeneration
- Fritsche, Lars G
- Chen, Wei
- Schu, Matthew
- Yaspan, Brian L
- Yu, Yi
- Thorleifsson, Gudmar
- Zack, Donald J
- Arakawa, Satoshi
- Cipriani, Valentina
- Ripke, Stephan
- Igo, Robert P
- Buitendijk, Gabriëlle H S
- Sim, Xueling
- Weeks, Daniel E
- Guymer, Robyn H
- Merriam, Joanna E
- Francis, Peter J
- Hannum, Gregory
- Agarwal, Anita
- Armbrecht, Ana Maria
- Audo, Isabelle
- Aung, Tin
- Barile, Gaetano R
- Benchaboune, Mustapha
- Bird, Alan C
- Bishop, Paul N
- Branham, Kari E
- Brooks, Matthew
- Brucker, Alexander J
- Cade, William H
- Cain, Melinda S
- Campochiaro, Peter A
- Chan, Chi-Chao
- Cheng, Ching-Yu
- Chew, Emily Y
- Chin, Kimberly A
- Chowers, Itay
- Clayton, David G
- Cojocaru, Radu
- Conley, Yvette P
- Cornes, Belinda K
- Daly, Mark J
- Dhillon, Baljean
- Edwards, Albert O
- Evangelou, Evangelos
- Fagerness, Jesen
- Ferreyra, Henry A
- Friedman, James S
- Geirsdottir, Asbjorg
- Silvestri, Giuliana
DOIAbstract
Age-related macular degeneration (AMD) is a common cause of blindness in older individuals. To accelerate the understanding of AMD biology and help design new therapies, we executed a collaborative genome-wide association study, including >17,100 advanced AMD cases and >60,000 controls of European and Asian ancestry. We identified 19 loci associated at P <5 × 10(-8). These loci show enrichment for genes involved in the regulation of complement activity, lipid metabolism, extracellular matrix remodeling and angiogenesis. Our results include seven loci with associations reaching P <5 × 10(-8) for the first time, near the genes COL8A1-FILIP1L, IER3-DDR1, SLC16A8, TGFBR1, RAD51B, ADAMTS9 and B3GALTL. A genetic risk score combining S...
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