Simultaneous Determination of Ramipril,

ABSTRACT: A simple, fast and precise multicomponent mode analysis method has been developed for simultaneous determination of Ramipril (RMP), Hydrochlorothiazide (HCT) and Telmisartan (TEL) in tablet formulation. The wavelengths selected for these drugs were 218nm, 271nm and 296nm respectively using methanol as solvent. The linearity for these drugs at all the selected wavelengths lies between 0.5-3.5 gml-1for RP, 1.25-8.75 gml-1for HCT and 4-28 gml-1for TEL. The concentrations of these drugs were evaluated in laboratory mixture and marketed formulation. Accuracy was determined by recovery studies from tablet dosages forms and ranges from 99.09-99.52%. Precision of method was find out as repeatability, day to day and analyst to analyst variation and shows the values within acceptable limit (R.S.D. 2 percent)