RELATIONSHIP BETWEEN HELICOBACTER PYLORI SEROPOSITIVITY AND HYPEREMESIS GRAVIDARUM

Abstract- Severe nausea and vomiting associated with weight loss, ketonemia, and electrolyte imbalance in pregnancy is called hyperemesis gravidarum (HG). Its cause is unknown but there are some hypotheses like hormonal mechanisms, psychological and emotional factors and Helicobacter pylori infection. The aim of this study was to find an association between (HG) and H. pylori infection. For this purpose in a prospective study from Aug. 2001 to Feb. 2002, the serum antibodies against H. pylori in 39 patients with HG was compared with IgG titers of 55 asymptomatic pregnant women at the same gestational age as controls. Venous blood was taken after the patients had given their written consent. Specific serum antibodies (immunoglobulin IgG) directed against H. pylori was measured by fluorescent enzyme-immunoassay. IgG titers less than 15 was considered negative, IgG titers more than 20 were regarded positive and IgG titers between 15-20 were considered as suspicious and required repeating the test after 2-4 weeks. Chi square, Mann Whitney and Student t test were used for statistical analysis of the data. Positive serum IgG concentrations were found in 26 of the 39 hyperemesis patients (66.7%) compared with 23 of 55 controls (41.8%). The difference was statistically significant (P<0.015). The mean IgG titers in hyperemesis group were 25 compared to 10.5 in control group (P<0.05). It seems that H. pylori infection is significantly associated with HG