Microscopic modeling of NO and S-nitrosoglutathione kinetics and transport in human airways

modeling of NO and S-nitrosoglutathione kinetics and trans-port in human airways. J Appl Physiol 90: 777–788, 2001.—Nitric oxide (NO) appears in the exhaled breath and is elevated in inflammatory diseases. We developed a steady-state mathematical model of the bronchial mucosa for normal small and large airways to understand NO and S-nitrosoglu-tathione (GSNO) kinetics and transport using data from the existing literature. Our model predicts that mean steady-state NO and GSNO concentrations for large airways (gen-eration 1) are 2.68 nM and 113 pM, respectively, in the epithelial cells and 0.11 nM (;66 ppb) and 507 nM in the mucus. For small airways (generation 15), the mean concen-trations of NO and GSNO, respectively, are 0.26 nM and 21 pM in the epithelial cells and 0.02 nM (;12 ppb) and 132 nM in the mucus. The concentrations in the mucus compar