SPECTROPHOTOMETRIC ESTIMATION OF ERDOSTEINE IN PHARMACEUTICAL DOSAGE FORM

ABSTRACT: Three simple, precise and economical UV methods have been developed for the estimation of Erdosteine in pharmaceutical dosage form. Erdosteine has the absorbance maxima at 235.0 nm (Method A), and in the first order derivative spectra, showed sharp peak at 227.5 nm (Method B). Method C applied was area under curve (AUC), in the wavelength range of 240.0-230.0 nm. Linearity for detector response was observed in the concentration range of 10-50 µg/ml for all three methods. The proposed methods were successfully applied for the simultaneous determination of Erdosteine in commercial pharmaceutical preparation. The results of the capsule analysis were validated statistically and by recovery studies and were found to be satisfactory