Inhibitor p27Kip1: a Strategy for Breast Cancer Gene Therapy

Cyclin-dependent kinase inhibitors play a critical role in regulating progres-sion of the eukaryotic cell through the cell cycle by associating with protein complexes composed of cyclins and cy-clin-dependent kinases and thus down-modulating the activity of the cyclin-dependent kinases (1). Pathways involving cyclin-dependent kinase in-hibitors are frequently disrupted in can-cer cells, and this disruption leads to ab-normal regulation of the cell cycle. Overexpression of cyclin-dependent ki-nase inhibitors leads to the arrest of cells at one of the checkpoints in the cel