Novel Macrocyclic Receptors for Peptides

The creation of synthetic molecules having selective peptide-binding properties seen in biological systems such as enzymes and antibodies is a challenging problems both in chemistry and biology.1 Through studies on the selective peptide-binding receptors, understanding of molecular recognition mechanisms seen in biological systems would be improved, and the potential applications to synthetic, separative and analytical purposes would be anticipated. Although it is known that several synthetic receptors bind with the certain peptides selectively,2 the search for new peptide substrates is continuing to establish the underlining principles in the design of selective receptors for a given peptide substrate. Recently, molecular receptors capable of interacting selectively with other molecules have been described. Fo