Letter to the Editor: Ratio of Bone Marrow Reticulocytes to Peripheral Corrected Reticulocytes for Evaluating Ineffective Erythropoiesis

Premature destruction of erythroid precursors in bone marrow is termed ineffective erythropoiesis. Ineffective erythropoiesis normally occurs in <10% of developing cells [1]. Much larger numbers of cells are lost in myelodysplastic syndromes (MDS), hemoglobinopathies, congenital dyserythropoietic anemias, and megaloblastic anemia. MDS are characterized by blood cytopenia despite the presence of a hypercellular marrow [2]. It is difficult to measure the degree of ineffective erythropoiesis. Few studies have examined the significance of reticulocyte fraction rate in each compartment (bone marrow and peripheral blood). This study investigated the efficacy of the ratio of bone marrow reticulocytes to peripheral correcte