Imaging Characteristics of Diffuse Primary Cutaneous B-Cell Lymphoma of the Cranial Vault with Orbital and Brain Invasion

Summary: We herein present the imaging findings in a case of diffuse primary cutaneous B-cell lymphoma of the cranial vault with orbital and brain invasion. MR imaging revealed first concomitant orbital and parenchymal inva-sion in a case of primary diffuse non-Hodgkin lymphoma of the cranial vault. Contrast-enhanced MR imaging revealed a diffuse mass in the scalp of the frontoparietal region bilaterally and invasion of the right orbit and left fronto-parietal lobe. Histologic and immunopathologic examina-tions revealed diffuse primary cutaneous B-cell lymphoma. Non-Hodgkin lymphoma represents only 3 % to 4% of all neoplasms in the general population; however, it occurs more frequently in patients with AIDS. Di-rect involvement of the CNS occurs in only 1 % to 2% of patients with lymphoma (1, 2). A literature searc