Trends in lung cancer incidence by histological type in

Background: In Japan, an increase in age-adjusted incidence rates of lung adenocarcinoma (ADC) and a decrease in lung squamous cell carcinoma (SQCC) have been reported. Methods: The number of lung cancer incidence, age-adjusted rates, and age-specific rates by birth-cohort according to histological type were examined using the data from Osaka Cancer Registry. Results: The numbers of lung cancer incidence among men and women have increased, particularly in ADC. The age-adjusted incidence rates of ADC among men and women have continuously increased, while those of SQCC and small cell carcinoma (SMCC) turned to decrease since 1990s. A trough of lung cancer incidence rates was observed among men in 1935–39 birth-cohorts. The declining trend appeared in 1955–59 birth-cohorts. Lung cancer incidence rates among women have increased since 1895–99 birth-cohorts, but those rates leveled off or decreased in 1950s birth-cohorts. Trends of ADC by birth-cohort were almost the same as those of all histological types. The SQCC among men peaked in 1915–19 birth-cohorts, and decreased in the subsequent birth-cohorts. The SMCC among men peaked in 1920s birth-cohorts, and decreased or leveled off in the subsequent birth-cohorts