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Context: Interventions that influence spirituality are needed if we are to obtain convincing evidence that spirituality has health benefits as suggested by epidemiological studies. There has been little research on identifying or developing such interventions. Objective: To evaluate the extent to which participation in a medically based lifestyle change program resulted in changes in spirituality, and whether changes in spirituality were related to certain components of the program and to changes in well-being, meaning in life, and tendency to become angry. Design: Participants filled out questionnaires at the beginning and end of the program