Improvement of physicomechanical properties of carbamazepine by recrystallization at different pH values

The morphology of crystals has an appreciable impact role on the physicochemical properties of drugs. Drug properties such as flowability, dissolution, hardness and bioavailability may be affected by crystallinity behaviours of drugs. The objective of this study was to achieve an improved physicomechanical property of carbamazepi-ne powder through recrystallization from aqueous solu-tions at different pH values. For this purpose, carbama-zapine was recrystallized from aqueous solutions at different pH values (1, 7, 11). The morphology of crystals was investigated using scanning electron microscopy; X-ray powder diffraction (XRPD) was used to identify polymor-phism; thermodynamic properties were analyzed using differential scanning calorimetery (DSC). Dissolution ra-te was determined using USP dissolution apparatus. Me