The mechanism by which dementia occurs in patients with Alzheimer’s disease (AD) is not known. We assessed changes in hippocampal dendritic spines of APP/PS1 transgenic mice that accumulate amyloid beta throughout the brain. Three-dimensional analysis of 21 507 dendritic spines in the dentate gyrus, a region crucial for learning and memory, revealed a substantial decrease in the frequency of large spines in plaque-free regions of APP/PS1 mice. Plaque-related dendrites also show striking alterations in spine density and morphology. However, plaques occupy only 3.9% of the molecular layer volume. Because large spines are considered to be the physical traces of long-term memory, widespread decrease in the frequency of large spines likely contr...
Alzheimer’s disease is regarded as a synaptopathy with a long presymptomatic phase. Soluble, oligome...
Alzheimer’s disease (AD), a neurodegenerative disorder initially characterized by mild memory impai...
ABSTRACT: In the context of Alzheimer’s disease (AD), hippocampal alterations have been well describ...
International audienceAlzheimer's disease (AD) is associated with a progressive loss of synapses and...
Dendritic spines, the site of most excitatory synapses in the brain, are lost in Alzheimer’s disease...
SAMP8 is a strain of mice with accelerated senescence. These mice have recently been the focus of at...
Dendritic spines are tiny protrusions along dendrites, which constitute major postsynaptic sites for...
Abstract. SAMP8 is a strain of mice with accelerated senescence. These mice have recently been the f...
SAMP8 is a strain of mice with accelerated senescence. These mice have recently been the focus of at...
Dendritic spines are tiny protrusions along dendrites, which constitute major postsynaptic sites for...
The pathology of Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-b (Ab) pep...
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) pep...
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) pep...
Abstract Amyloid-beta plaque deposition represents a major neuropathological hallmark of Alzheimer’s...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioratio...
Alzheimer’s disease is regarded as a synaptopathy with a long presymptomatic phase. Soluble, oligome...
Alzheimer’s disease (AD), a neurodegenerative disorder initially characterized by mild memory impai...
ABSTRACT: In the context of Alzheimer’s disease (AD), hippocampal alterations have been well describ...
International audienceAlzheimer's disease (AD) is associated with a progressive loss of synapses and...
Dendritic spines, the site of most excitatory synapses in the brain, are lost in Alzheimer’s disease...
SAMP8 is a strain of mice with accelerated senescence. These mice have recently been the focus of at...
Dendritic spines are tiny protrusions along dendrites, which constitute major postsynaptic sites for...
Abstract. SAMP8 is a strain of mice with accelerated senescence. These mice have recently been the f...
SAMP8 is a strain of mice with accelerated senescence. These mice have recently been the focus of at...
Dendritic spines are tiny protrusions along dendrites, which constitute major postsynaptic sites for...
The pathology of Alzheimer’s disease (AD) is characterized by the accumulation of amyloid-b (Ab) pep...
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) pep...
The pathology of Alzheimer's disease (AD) is characterized by the accumulation of amyloid-β (Aβ) pep...
Abstract Amyloid-beta plaque deposition represents a major neuropathological hallmark of Alzheimer’s...
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by a deterioratio...
Alzheimer’s disease is regarded as a synaptopathy with a long presymptomatic phase. Soluble, oligome...
Alzheimer’s disease (AD), a neurodegenerative disorder initially characterized by mild memory impai...
ABSTRACT: In the context of Alzheimer’s disease (AD), hippocampal alterations have been well describ...
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