Interactions between Myosin Crosslinkers Control Cytokin Contractility Dynamics and M

cumferential cytoskeletal array. Furthermore, myosin-II and actin crosslinkers may influence each other as they modulate the dynamics and mechanics of cell-shape change. linkers and myosin-II may modulate each other’s activities. Finally, it is not understood how the cleavage furrows of wild-type cells constrict in such a stereotypical fashion nor how cleavage furrow ingression can occur without myosin-II. To address these questions, we use the model system Dictyostelium to study cytokinesis cell-shape change. This or-ganism performs cytokinesis in a similar fashion to many types of mammalian cell culture cells and is readily amenable to me-chanical and genetic interaction studies. By using this system