Add to ORKGage has been identified at multiple chromosomal sites (i.e., loci) in lung cancer cells. We questioned whether similar damage could be detected in the bronchial epithelial cells of chronic smokers who do not have this disease. Methods: Biopsy specimens from six different bronchial regions were ob-tained from 54 chronic smokers (40 current smokers and 14 former smok-ers). The presence of squamous meta-plasia and dysplasia (abnormal histo-logic changes) in the specimens was documented by examination of hema-toxylin–eosin-stained sections, and
Purpose Cigarette smoking is the major pathogenic factor for lung cancer. The precise mechanisms of ...
Abstract Lung cancer is the leading cause of cancer-related death in the world. In contrast to many ...
Cigarette smoke (CS)-mediated oxidative stress induces several signaling cascades, including kinases...
Background: Most lung cancers are attributed to smoking. These cancers have been associated with mul...
Most lung cancer is attributed to long-term smoking. In order to define chromosomal regions with an ...
Background: Molecular abnormalifies occurring in bronohogenic carcinoma are also found in morphologi...
Cigarette smoking is the main risk factor for the development of squamous cell lung carcinoma (SCC)....
Based on a variety of clinical (1,2), histologic (3,4), cytoge-netic (5–7), and molecular (8–10) dat...
Cigarette smoking is the leading risk factor for lung cancer. To identify genes deregulated by smoki...
Lung cancer is the leading cause of cancer death in the United States, accounting for approximately ...
AIMS:To quantify the extent of squamous metaplasia in bronchial biopsies and relate it to the presen...
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend ...
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend ...
BACKGROUND. Lung carcinoma is a common malignancy, and tobacco carcinogenesis is the major cause. St...
Early identification and subsequent intervention are needed to decrease the high mortality rate asso...
Purpose Cigarette smoking is the major pathogenic factor for lung cancer. The precise mechanisms of ...
Abstract Lung cancer is the leading cause of cancer-related death in the world. In contrast to many ...
Cigarette smoke (CS)-mediated oxidative stress induces several signaling cascades, including kinases...
Background: Most lung cancers are attributed to smoking. These cancers have been associated with mul...
Most lung cancer is attributed to long-term smoking. In order to define chromosomal regions with an ...
Background: Molecular abnormalifies occurring in bronohogenic carcinoma are also found in morphologi...
Cigarette smoking is the main risk factor for the development of squamous cell lung carcinoma (SCC)....
Based on a variety of clinical (1,2), histologic (3,4), cytoge-netic (5–7), and molecular (8–10) dat...
Cigarette smoking is the leading risk factor for lung cancer. To identify genes deregulated by smoki...
Lung cancer is the leading cause of cancer death in the United States, accounting for approximately ...
AIMS:To quantify the extent of squamous metaplasia in bronchial biopsies and relate it to the presen...
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend ...
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend ...
BACKGROUND. Lung carcinoma is a common malignancy, and tobacco carcinogenesis is the major cause. St...
Early identification and subsequent intervention are needed to decrease the high mortality rate asso...
Purpose Cigarette smoking is the major pathogenic factor for lung cancer. The precise mechanisms of ...
Abstract Lung cancer is the leading cause of cancer-related death in the world. In contrast to many ...
Cigarette smoke (CS)-mediated oxidative stress induces several signaling cascades, including kinases...