Because the pathogenetic understanding of diabetic vascular complications remains fragmentary, and even the best available interventions may prove insufficient to arrest the progression of certain lesions, new avenues of investigation should be pursued. One of these should be the early in vivo investigation of the cells that endure the pathological process (pericytes and endothelial and mesangial cells), preferably in humans. The abnormal vascular architecture (i.e., capillary acellularity, microaneurysms, thickened basement membranes, and mesangial expansion) and the hemostatic and hemodynamic alterations observed in diabetes point to an adaptivelmaladaptive replicative and biosynthetic program triggered by the metabolic perturbation, but ...
Several thrombogenic abnormalities are associated with diabetes. Since endothelial dysfunction occur...
D iabetes complications represent ahuge burden for patients and healthservices. The fight against ea...
The article deals with the integrated characteristics of hyperglycemia role in the pathogenesis of v...
The late complications of diabetes represent in large part microvascular dysfunction. The developmen...
AIMS: Vascular endothelial cells play a major role in maintaining cardiovascular homeostasis in he...
Diabetes-associated vascular complications are collectively the major clinical problems facing patie...
Abnormal endothelial function plays a pivota role in the pathogenesis of diabetic complications. Due...
The diabetes mellitus (DM) inevitably progresses and leads to complications, among which the main pl...
Although the mechanisms by which insulin-resistance and hyperglycemia lead to cardiovascular disease...
Traditionally, the development of diabetic complications has been attributed to the biochemical path...
The endothelium is a complex organ with a multitude of properties essential for control of vascular ...
Over recent years, the explosive increase in the worldwideprevalence of type 2 diabetes has transfo...
Diabetes causes severe pathological changes to the microvasculature in many organs and tissues and i...
Diabetic complications represent a huge burden for patients and health services. The fight against e...
Vascular disease remains a major cause of morbidity and mortality in diabetes mellitus, in spite of ...
Several thrombogenic abnormalities are associated with diabetes. Since endothelial dysfunction occur...
D iabetes complications represent ahuge burden for patients and healthservices. The fight against ea...
The article deals with the integrated characteristics of hyperglycemia role in the pathogenesis of v...
The late complications of diabetes represent in large part microvascular dysfunction. The developmen...
AIMS: Vascular endothelial cells play a major role in maintaining cardiovascular homeostasis in he...
Diabetes-associated vascular complications are collectively the major clinical problems facing patie...
Abnormal endothelial function plays a pivota role in the pathogenesis of diabetic complications. Due...
The diabetes mellitus (DM) inevitably progresses and leads to complications, among which the main pl...
Although the mechanisms by which insulin-resistance and hyperglycemia lead to cardiovascular disease...
Traditionally, the development of diabetic complications has been attributed to the biochemical path...
The endothelium is a complex organ with a multitude of properties essential for control of vascular ...
Over recent years, the explosive increase in the worldwideprevalence of type 2 diabetes has transfo...
Diabetes causes severe pathological changes to the microvasculature in many organs and tissues and i...
Diabetic complications represent a huge burden for patients and health services. The fight against e...
Vascular disease remains a major cause of morbidity and mortality in diabetes mellitus, in spite of ...
Several thrombogenic abnormalities are associated with diabetes. Since endothelial dysfunction occur...
D iabetes complications represent ahuge burden for patients and healthservices. The fight against ea...
The article deals with the integrated characteristics of hyperglycemia role in the pathogenesis of v...