DEVELOPMENT AND STATISTICAL VAIDATION OF SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF MOSAPRIDE IN PHARMACEUTICAL FORMULATION

ABSTRACT: Three simple, precise and economical UV methods have been developed for the estimation of Mosapride in bulk and pharmaceutical formulations. Mosapride has the absorbance maxima at 309nm (Method A), and in the first order derivative spectra, showed zero crossing at 309 nm, with a sharp peak at 300 nm when n=1 (Method B), Method C applied was Area Under Curve (AUC) for analysis of Mosapride in the wavelength range of 300-320nm. Drug followed the Beer’s Lamberts range of 5-40 µg/ml for the method A, B C. Results of analysis were validated statistically and by recovery studies and were found to be satisfactory