Thanges in Concanavalin A-Reactive Proteins in Inflammatory Disorders

)uantitatiVe changes of concanaValin A (Con A)-reactive troteins in serum samples obtained from rats with induced iflammation and from patients with inflammatory and au-Dimmune diseases were examined by use of lectin blots. reatment of rats with a single dose of fermented yeast to iduce inflammation caused an extensive increase in Con li-reactivity. These changes were time dependent and were imilar in both sexes of the animals. When we examined erum samples obtained from patients with various inf lam-natory disorders for their Con A-reactive proteins as com-lared with normal donors, we noted that the Con A-reactivity icreased in patients with rheumatoid arthritis and systemic.ipus erythematosus. Among all the glycoproteins examined y lectin blots with use of Con A, a set of five proteins was elected for detailed analysis by densitometric scanning. #{149}heseincluded a2-macroglobulin, P-i 50, P-95, P-40, an